Belonging to an intersex third gender that originated during the hundreds of years of human emigration into space, Izana is also a Garde pilot and quickly becomes Nagate's best friend and eventual roommate, later falling in love with him. This attraction causes Izana's body to undergo a transformation into that of a female. Izana loses an arm and a leg during a battle against the Gauna and has them replaced with prosthetic limbs that allow her to operate complex machinery with far more skill than an ordinary person.
A system is also installed on Izana's Garde unit that funnels sensor and radar information directly into her brain via her artificial arm, granting her unparalleled detection abilities surpassing even Sidonia's systems. She is often assigned to recon and spotting duties in battle. Initially TS-291, Izana is later assigned to unit 723. Ten years after the destruction of the Large Mass Union Ship and Sidonia's colonization of the Lem star system. Izana is one of several crew members to depart on a repaired Sidonia to parts unknown.
Izana is referred to using gender neutral pronouns in the original Japanese dialogue. Because the English language lacks an appropriate equivalent, she is often referred to using feminine pronouns.