Anna’s breakout role was in 2014’s Frankenstein, MD as Victoria Frankenstein. After making guest appearances on Natural 20 and Faking It, she would star in the 2016 webseries The Friendless Five as Brie. The following year, she was cast in the sci-fi/comedy series Miss 2059, based on Anna Akana’s 2014 short film Miss Earth. In addition to appearing in a number of short films, Lore voiced Chloe Turner in the podcast series The Bright Sessions.
In 2018, Lore starred in the titular role of Katie, a comedy miniseries. After a two-episode guest appearance in the HBO Max DC series Doom Patrol as Penny Farthing, Lore landed a recurring role as Carrie in All American. She also starred in the 2022 Peacock Original film They/Them